TeesRep Collection:
http://hdl.handle.net/10149/47236
Wed, 07 Dec 2016 00:17:22 GMT2016-12-07T00:17:22ZAcute exercise and appetite-regulating hormones in overweight and obese individuals: A meta-analysis
http://hdl.handle.net/10149/620644
Title: Acute exercise and appetite-regulating hormones in overweight and obese individuals: A meta-analysis
Authors: Douglas, J. A. (Jessica Anne); Deighton, K. (Kevin); Atkinson, J. (Janet); Sari-Sarraf, V. (Vahid); Stensel, D. J. (David John); Atkinson, G. (Greg)
Abstract: In lean individuals, acute aerobic exercise is reported to transiently suppress sensations of appetite, suppress blood-concentrations of acylated ghrelin (AG) and increase glucagon-like peptide-1 (GLP-1) and peptide-YY (PYY). Findings in overweight/obese individuals have yet to be synthesised.
In this systematic review and meta-analysis, we quantified the effects acute exercise has on AG, total PYY and GLP-1 in overweight/obese individuals. The potential for body mass index (BMI) to act as a moderator for AG was also explored.
Six published studies (73 participants, 78% male, mean BMI: 30.6 kg.m-2) met the inclusion criteria. Standardised mean differences (SMD) and standard errors were extracted for AG, total PYY and GLP-1 concentrations in control and exercise trials and synthesised using a random effects meta-analysis model. BMI was the predictor in a meta-regression for AG.
Exercise moderately suppressed AG area-under-the-curve concentrations (pooled SMD -0.34, 95%CI: -0.53 to -0.15). The magnitude of this reduction was greater for higher mean BMIs (pooled meta-regression slope: -0.04 SMD/kg.m-2 (95%CI: -0.07 to 0.00)). Trivial SMDs were obtained for total PYY (0.10, 95%CI: -0.13 to 0.31) and GLP-1 (-0.03, 95%CI: -0.18 to 0.13).
This indicates that exercise in overweight/obese individuals moderately alters AG in a direction that could be associated with decreased hunger and energy intake. (PROSPERO registration: CRD42014006265).Fri, 01 Jan 2016 00:00:00 GMThttp://hdl.handle.net/10149/6206442016-01-01T00:00:00ZGoing far beyond the evidence
http://hdl.handle.net/10149/620641
Title: Going far beyond the evidence
Authors: Handoll, H. H. G. (Helen); Brealey, S. (Stephen); Keding, A. (Ada); Rangan, A. (Amar)Thu, 20 Oct 2016 00:00:00 GMThttp://hdl.handle.net/10149/6206412016-10-20T00:00:00ZClarifications on the design and conduct of the PROFHER trial
http://hdl.handle.net/10149/620640
Title: Clarifications on the design and conduct of the PROFHER trial
Authors: Handoll, H. H. G. (Helen); Keding, A. (Ada); Brealey, S. (Stephen); Rangan, A. (Amar)Tue, 25 Oct 2016 00:00:00 GMThttp://hdl.handle.net/10149/6206402016-10-25T00:00:00ZSize-exponents for scaling maximal oxygen uptake in over 6500 humans: a systematic review and meta-analysis
http://hdl.handle.net/10149/620639
Title: Size-exponents for scaling maximal oxygen uptake in over 6500 humans: a systematic review and meta-analysis
Authors: Lolli, L. (Lorenzo); Batterham, A. M. (Alan); Weston, K. (Kathryn); Atkinson, G. (Greg)
Abstract: Background: Maximal oxygen uptake (V̇ O2max) is conventionally normalized to body size as a simple ratio or using an allometric exponent < 1. Nevertheless, the most appropriate body size variable to use for scaling and the value of the exponent are still enigmatic. Studies tend to be based on small samples and can, therefore, lack precision.
Objective: To provide a quantitative synthesis of reported static allometric exponents used for scaling V̇ O2max to whole body mass and fat-free mass.
Methods: Eight electronic databases (CINAHL, Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE, PubMed, Scopus, SPORTDiscus and Web of Science) were searched for relevant studies published up to January 2016. Search terms included ‘oxygen uptake’, ‘cardiorespiratory fitness’, ‘V̇ O2max’, ‘V̇ O2peak’, ‘scaling’ and all interchangeable terms. Inclusion criteria included human cardiorespiratory fitness data; cross-sectional study designs; an empirical derivation of the exponent;
reported precision statistics; and reported information regarding participant sex, age and sports background, V̇ O2max protocol, body composition protocol and line-fitting methods. A random-effects model was used to quantify weighted pooled exponents and 95% confidence limits (95% CL). Heterogeneity was quantified with the tau-statistic (τ). Meta-regression was used to quantify the impact of selected moderator variables on the exponent effect size. A 95% prediction interval (95% PI) was calculated to quantify the likely range of true fat-free mass exponents in similar future studies, with this distribution used to estimate the probability that an exponent would be above theorised universal values of ⅔ and ¾.
Results: Thirty-six studies, involving 6,514 participants, met the eligibility criteria. Whole-body mass and fat-free mass was used as the scaling denominator in 27 studies and 15 studies, respectively. The pooled allometric exponent (95% CL) was found to be 0.70 (0.64 to 0.76) for body mass and 0.90 (0.83 to 0.96)
for fat-free mass. The between-study heterogeneity was greater for whole-body mass (τ = ± 0.15) vs. fat
free mass (τ = ± 0.11). Participant sex explained 30% of the between-study variability in the whole-body
mass exponent, but the influence on the fat-free mass exponent was trivial. The body mass exponent of
0.52 (0.40 to 0.64) for females was substantially lower than the 0.76 (0.70 to 0.83) for males, whereas the fat-free mass exponent was similar for both sexes. The effects of all other moderators were trivial. The 95% PI for fat-free mass ranged from 0.68 to 1.12. The estimated probability of a true fat-free mass exponent in a future study being greater than ⅔- or ¾-power scaling is 0.98 (very likely) and 0.92 (likely), respectively.
Conclusions: In this quantitative synthesis of published studies involving over 6,500 humans, the body mass exponent was found to be spuriously low and prone to substantial heterogeneity. We conclude that
the scaling of V̇ O2max in humans is consistent with the allometric cascade model with an estimated prediction interval for the fat-free mass exponent not likely to be consistent with the ⅔ and ¾ power laws.Fri, 01 Jan 2016 00:00:00 GMThttp://hdl.handle.net/10149/6206392016-01-01T00:00:00Z