Quadriceps force generation in patients with osteoarthritis of the knee and asymptomatic participants during patellar tendon reflex reactions: an exploratory cross-sectional study

Hdl Handle:
http://hdl.handle.net/10149/58197
Title:
Quadriceps force generation in patients with osteoarthritis of the knee and asymptomatic participants during patellar tendon reflex reactions: an exploratory cross-sectional study
Authors:
Dixon, J. (John); Howe, T. E. (Tracey)
Affiliation:
University of Teesside. Teesside Centre for Rehabilitation Sciences; The James Cook University Hospital; Glasgow Caledonian University. HealthQWest.
Citation:
Dixon, J. and Howe, T. E. (2005) 'Quadriceps force generation in patients with osteoarthritis of the knee and asymptomatic participants during patellar tendon reflex reactions: an exploratory cross-sectional study', BMC Musculoskeletal Disorders, 6 (46), pp.1-6.
Publisher:
BioMed Central
Journal:
BMC Musculoskeletal Disorders
Issue Date:
Sep-2005
URI:
http://hdl.handle.net/10149/58197
DOI:
10.1186/1471-2474-6-46
Abstract:
Background: It has been postulated that muscle contraction is slower in patients with osteoarthritis of the knee than asymptomatic individuals, a factor that could theoretically impair joint protection mechanisms. This study investigated whether patients with osteoarthritis of the knee took longer than asymptomatic participants to generate force during reflex quadriceps muscle contraction. This was an exploratory study to inform sample size for future studies. Methods: An exploratory observational cross sectional study was carried out. Two subject groups were tested, asymptomatic participants (n = 17), mean (SD) 56.7 (8.6) years, and patients with osteoarthritis of the knee, diagnosed by an orthopaedic surgeon, (n = 16), age 65.9 (7.8) years. Patellar tendon reflex responses were elicited from participants and measured with a load cell. Force latency, contraction time, and force of the reflex response were determined from digitally stored data. The Mann-Whitney U test was used for the between group comparisons in these variables. Bland and Altman within-subject standard deviation values were calculated to evaluate the measurement error or precision of force latency and contraction time. Results: No significant differences were found between the groups for force latency (p = 0.47), contraction time (p = 0.91), or force (p = 0.72). The two standard deviation measurement error values for force latency were 27.9 ms for asymptomatic participants and 16.4 ms for OA knee patients. For contraction time, these values were 29.3 ms for asymptomatic participants and 28.1 ms for OA knee patients. Post hoc calculations revealed that the study was adequately powered (80%) to detect a difference between the groups of 30 ms in force latency. However it was inadequately powered (59%) to detect this same difference in contraction time, and 28 participants would be required in each group to reach 80% power. Conclusion: Patients with osteoarthritis of the knee do not appear to have compromised temporal parameters or magnitude of force generation during patellar tendon reflex reactions when compared to a group of asymptomatic participants. However, these results suggest that larger studies are carried out to investigate this area further.
Type:
Article
Keywords:
osteoarthritis; knee; force generation; quadriceps; muscle contraction; patellar; tendon reflex
ISSN:
1471-2474
Rights:
Author can archive publisher's version/PDF. For full details see http://www.sherpa.ac.uk/romeo/ [Accessed 11/01/2010]
Citation Count:
2 [Scopus, 11/01/2010]

Full metadata record

DC FieldValue Language
dc.contributor.authorDixon, J. (John)-
dc.contributor.authorHowe, T. E. (Tracey)-
dc.date.accessioned2009-04-01T10:45:41Z-
dc.date.available2009-04-01T10:45:41Z-
dc.date.issued2005-09-
dc.identifier.citationBMC Musculoskeletal Disorders; 6 (46): 1-6-
dc.identifier.issn1471-2474-
dc.identifier.doi10.1186/1471-2474-6-46-
dc.identifier.urihttp://hdl.handle.net/10149/58197-
dc.description.abstractBackground: It has been postulated that muscle contraction is slower in patients with osteoarthritis of the knee than asymptomatic individuals, a factor that could theoretically impair joint protection mechanisms. This study investigated whether patients with osteoarthritis of the knee took longer than asymptomatic participants to generate force during reflex quadriceps muscle contraction. This was an exploratory study to inform sample size for future studies. Methods: An exploratory observational cross sectional study was carried out. Two subject groups were tested, asymptomatic participants (n = 17), mean (SD) 56.7 (8.6) years, and patients with osteoarthritis of the knee, diagnosed by an orthopaedic surgeon, (n = 16), age 65.9 (7.8) years. Patellar tendon reflex responses were elicited from participants and measured with a load cell. Force latency, contraction time, and force of the reflex response were determined from digitally stored data. The Mann-Whitney U test was used for the between group comparisons in these variables. Bland and Altman within-subject standard deviation values were calculated to evaluate the measurement error or precision of force latency and contraction time. Results: No significant differences were found between the groups for force latency (p = 0.47), contraction time (p = 0.91), or force (p = 0.72). The two standard deviation measurement error values for force latency were 27.9 ms for asymptomatic participants and 16.4 ms for OA knee patients. For contraction time, these values were 29.3 ms for asymptomatic participants and 28.1 ms for OA knee patients. Post hoc calculations revealed that the study was adequately powered (80%) to detect a difference between the groups of 30 ms in force latency. However it was inadequately powered (59%) to detect this same difference in contraction time, and 28 participants would be required in each group to reach 80% power. Conclusion: Patients with osteoarthritis of the knee do not appear to have compromised temporal parameters or magnitude of force generation during patellar tendon reflex reactions when compared to a group of asymptomatic participants. However, these results suggest that larger studies are carried out to investigate this area further.-
dc.publisherBioMed Central-
dc.rightsAuthor can archive publisher's version/PDF. For full details see http://www.sherpa.ac.uk/romeo/ [Accessed 11/01/2010]-
dc.subjectosteoarthritis-
dc.subjectknee-
dc.subjectforce generation-
dc.subjectquadriceps-
dc.subjectmuscle contraction-
dc.subjectpatellar-
dc.subjecttendon reflex-
dc.titleQuadriceps force generation in patients with osteoarthritis of the knee and asymptomatic participants during patellar tendon reflex reactions: an exploratory cross-sectional study-
dc.typeArticle-
dc.contributor.departmentUniversity of Teesside. Teesside Centre for Rehabilitation Sciences; The James Cook University Hospital; Glasgow Caledonian University. HealthQWest.-
dc.identifier.journalBMC Musculoskeletal Disorders-
ref.assessmentRAE 2008-
ref.citationcount2 [Scopus, 11/01/2010]-
or.citation.harvardDixon, J. and Howe, T. E. (2005) 'Quadriceps force generation in patients with osteoarthritis of the knee and asymptomatic participants during patellar tendon reflex reactions: an exploratory cross-sectional study', BMC Musculoskeletal Disorders, 6 (46), pp.1-6.-
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