Dietary fat intake and prevention of cardiovascular disease: systematic review

Hdl Handle:
http://hdl.handle.net/10149/58205
Title:
Dietary fat intake and prevention of cardiovascular disease: systematic review
Authors:
Hooper, L. (Lee); Summerbell, C. D. (Carolyn); Higgins, J. P. T. (Julian); Thompson, R. L. (Rachel); Capps, N. E. (Nigel); Smith, G. D. (George); Riemersma, R. A (Rudolph); Ebrahim, S. B. J. (Shah)
Affiliation:
University Dental Hospital of Manchester. Manchester Dental and Education Centre (MANDEC); University of Teesside. School of Health; Institute of Child Health. Systematic Reviews Training Unit; Southampton General Hospital. Institute of Human Nutrition. Public Health Nutrition; Princess Royal Hospital NHS Trust. Department of Clinical Biochemistry; University of Bristol. Department of Social Medicine; University of Edinburgh. Cardiovascular Research.
Citation:
Hooper, L. et al. (2001) 'Dietary fat intake and prevention of cardiovascular disease: systematic review', BMJ, 322 (7289), pp.757-763.
Publisher:
BMJ Group
Journal:
BMJ
Issue Date:
Mar-2001
URI:
http://hdl.handle.net/10149/58205
DOI:
10.1136/bmj.322.7289.757
Abstract:
Objective: To assess the effect of reduction or modification of dietary fat intake on total and cardiovascular mortality and cardiovascular morbidity. Design: Systematic review. Data sources: Cochrane Library, Medline, Embase, CAB abstracts, SIGLE, CVRCT registry, and biographies were searched; trials known to experts were included. Included studies: Randomised controlled trials stating intention to reduce or modify fat or cholesterol intake in healthy adult participants over at least six months. Inclusion decisions, validity, and data extraction were duplicated. Meta-analysis (random effects methodology), meta-regression, and funnel plots were performed. Results: 27 studies (30 902 person years of observation) were included. Alteration of dietary fat intake had small effects on total mortality (rate ratio 0.98; 95% confidence interval 0.86 to 1.12). Cardiovascular mortality was reduced by 9% (0.91; 0.77 to 1.07) and cardiovascular events by 16% (0.84; 0.72 to 0.99), which was attenuated (0.86; 0.72 to 1.03) in a sensitivity analysis that excluded a trial using oily fish. Trials with at least two years' follow up provided stronger evidence of protection from cardiovascular events (0.76; 0.65 to 0.90). Conclusions: There is a small but potentially important reduction in cardiovascular risk with reduction or modification of dietary fat intake, seen particularly in trials of longer duration.
Type:
Article
Keywords:
cardiovascular disease; coronary heart disease; morbidity; mortality; dietary fat; diet; cardiovascular mortality; cardiovascular morbidity
ISSN:
1468-5833
Rights:
Author can archive publisher's version/PDF. For full details see http://www.sherpa.ac.uk/romeo/[Accessed 16/12/09]
Citation Count:
148 [Scopus, 16/12/09]

Full metadata record

DC FieldValue Language
dc.contributor.authorHooper, L. (Lee)-
dc.contributor.authorSummerbell, C. D. (Carolyn)-
dc.contributor.authorHiggins, J. P. T. (Julian)-
dc.contributor.authorThompson, R. L. (Rachel)-
dc.contributor.authorCapps, N. E. (Nigel)-
dc.contributor.authorSmith, G. D. (George)-
dc.contributor.authorRiemersma, R. A (Rudolph)-
dc.contributor.authorEbrahim, S. B. J. (Shah)-
dc.date.accessioned2009-04-01T10:45:54Z-
dc.date.available2009-04-01T10:45:54Z-
dc.date.issued2001-03-
dc.identifier.citationBMJ; 322 (7289): 757-763-
dc.identifier.issn1468-5833-
dc.identifier.doi10.1136/bmj.322.7289.757-
dc.identifier.urihttp://hdl.handle.net/10149/58205-
dc.description.abstractObjective: To assess the effect of reduction or modification of dietary fat intake on total and cardiovascular mortality and cardiovascular morbidity. Design: Systematic review. Data sources: Cochrane Library, Medline, Embase, CAB abstracts, SIGLE, CVRCT registry, and biographies were searched; trials known to experts were included. Included studies: Randomised controlled trials stating intention to reduce or modify fat or cholesterol intake in healthy adult participants over at least six months. Inclusion decisions, validity, and data extraction were duplicated. Meta-analysis (random effects methodology), meta-regression, and funnel plots were performed. Results: 27 studies (30 902 person years of observation) were included. Alteration of dietary fat intake had small effects on total mortality (rate ratio 0.98; 95% confidence interval 0.86 to 1.12). Cardiovascular mortality was reduced by 9% (0.91; 0.77 to 1.07) and cardiovascular events by 16% (0.84; 0.72 to 0.99), which was attenuated (0.86; 0.72 to 1.03) in a sensitivity analysis that excluded a trial using oily fish. Trials with at least two years' follow up provided stronger evidence of protection from cardiovascular events (0.76; 0.65 to 0.90). Conclusions: There is a small but potentially important reduction in cardiovascular risk with reduction or modification of dietary fat intake, seen particularly in trials of longer duration.-
dc.publisherBMJ Group-
dc.rightsAuthor can archive publisher's version/PDF. For full details see http://www.sherpa.ac.uk/romeo/[Accessed 16/12/09]-
dc.subjectcardiovascular disease-
dc.subjectcoronary heart disease-
dc.subjectmorbidity-
dc.subjectmortality-
dc.subjectdietary fat-
dc.subjectdiet-
dc.subjectcardiovascular mortality-
dc.subjectcardiovascular morbidity-
dc.titleDietary fat intake and prevention of cardiovascular disease: systematic review-
dc.typeArticle-
dc.contributor.departmentUniversity Dental Hospital of Manchester. Manchester Dental and Education Centre (MANDEC); University of Teesside. School of Health; Institute of Child Health. Systematic Reviews Training Unit; Southampton General Hospital. Institute of Human Nutrition. Public Health Nutrition; Princess Royal Hospital NHS Trust. Department of Clinical Biochemistry; University of Bristol. Department of Social Medicine; University of Edinburgh. Cardiovascular Research.-
dc.identifier.journalBMJ-
ref.assessmentRAE 2008-
ref.citationcount148 [Scopus, 16/12/09]-
or.citation.harvardHooper, L. et al. (2001) 'Dietary fat intake and prevention of cardiovascular disease: systematic review', BMJ, 322 (7289), pp.757-763.-
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