Optimizing the production of bacterial cellulose in surface culture: evaluation of substrate mass transfer influences on the bioreaction (Part 1)

Hdl Handle:
http://hdl.handle.net/10149/58361
Title:
Optimizing the production of bacterial cellulose in surface culture: evaluation of substrate mass transfer influences on the bioreaction (Part 1)
Authors:
Hornung, M. (Michael); Ludwig, M.; Gerrard, A. M. (Mark); Schmauder, H-P. (Hans Peter)
Affiliation:
Forschungszentrum für Medizintechnik und Biotechnologie. Germany; University of Teesside. School of Science and Technology.
Citation:
Hornung, M. et al. (2006) 'Optimizing the production of bacterial cellulose in surface culture: evaluation of substrate mass transfer influences on the bioreaction (Part 1)', Engineering in Life Sciences, 6 (6), pp.537-545.
Publisher:
Wiley-Blackwell
Journal:
Engineering in Life Sciences
Issue Date:
2006
URI:
http://hdl.handle.net/10149/58361
DOI:
10.1002/elsc.200620162
Abstract:
The interest in cellulose produced by bacteria from surface cultures has increased steadily in recent years because of its potential for use in medicine and cosmetics. Unfortunately, the low yield of the production process has limited the commercial usefulness of bacterial cellulose. This series of three papers dealing with the production of bacterial cellulose using (batch) surface culture, firstly present a complete and complex analysis of the overall system, which allows a fundamental optimization of the production process to be performed. This material has many applications but the low yield of the process limits its commercial usefulness. In part 1, the effect of the rate of mass transfer of substrate on the microbial process, which is characterized by the growth of the bacteria, product formation, and the utilization of the substrate by the bacteria, is studied. A fundamental model for the diffusion of glucose through the growing cellulose layer is proposed and solved. The model confirmed that the increase in diffusional resistance is indeed significant but other factors will also need to be taken into account.
Type:
Article
Keywords:
bacteria; biotechnology; cellulose; mass transfer; optimization; polymerization
ISSN:
1618-2863
Rights:
Subject to restrictions, author can archive post-print (ie final draft post-refereeing). For full details see http://www.sherpa.ac.uk/romeo/ [Accessed 13/01/2010]
Citation Count:
5 [Scopus, 13/01/2010]

Full metadata record

DC FieldValue Language
dc.contributor.authorHornung, M. (Michael)-
dc.contributor.authorLudwig, M.-
dc.contributor.authorGerrard, A. M. (Mark)-
dc.contributor.authorSchmauder, H-P. (Hans Peter)-
dc.date.accessioned2009-04-01T10:50:03Z-
dc.date.available2009-04-01T10:50:03Z-
dc.date.issued2006-
dc.identifier.citationEngineering in Life Sciences; 6 (6): 537-545-
dc.identifier.issn1618-2863-
dc.identifier.doi10.1002/elsc.200620162-
dc.identifier.urihttp://hdl.handle.net/10149/58361-
dc.description.abstractThe interest in cellulose produced by bacteria from surface cultures has increased steadily in recent years because of its potential for use in medicine and cosmetics. Unfortunately, the low yield of the production process has limited the commercial usefulness of bacterial cellulose. This series of three papers dealing with the production of bacterial cellulose using (batch) surface culture, firstly present a complete and complex analysis of the overall system, which allows a fundamental optimization of the production process to be performed. This material has many applications but the low yield of the process limits its commercial usefulness. In part 1, the effect of the rate of mass transfer of substrate on the microbial process, which is characterized by the growth of the bacteria, product formation, and the utilization of the substrate by the bacteria, is studied. A fundamental model for the diffusion of glucose through the growing cellulose layer is proposed and solved. The model confirmed that the increase in diffusional resistance is indeed significant but other factors will also need to be taken into account.-
dc.publisherWiley-Blackwell-
dc.rightsSubject to restrictions, author can archive post-print (ie final draft post-refereeing). For full details see http://www.sherpa.ac.uk/romeo/ [Accessed 13/01/2010]-
dc.subjectbacteria-
dc.subjectbiotechnology-
dc.subjectcellulose-
dc.subjectmass transfer-
dc.subjectoptimization-
dc.subjectpolymerization-
dc.titleOptimizing the production of bacterial cellulose in surface culture: evaluation of substrate mass transfer influences on the bioreaction (Part 1)-
dc.typeArticle-
dc.contributor.departmentForschungszentrum für Medizintechnik und Biotechnologie. Germany; University of Teesside. School of Science and Technology.-
dc.identifier.journalEngineering in Life Sciences-
ref.assessmentRAE 2008-
ref.citationcount5 [Scopus, 13/01/2010]-
or.citation.harvardHornung, M. et al. (2006) 'Optimizing the production of bacterial cellulose in surface culture: evaluation of substrate mass transfer influences on the bioreaction (Part 1)', Engineering in Life Sciences, 6 (6), pp.537-545.-
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