Neuropathology of Depression in Alzheimer's Disease: Current Knowledge and the Potential for New Treatments

Hdl Handle:
http://hdl.handle.net/10149/621769
Title:
Neuropathology of Depression in Alzheimer's Disease: Current Knowledge and the Potential for New Treatments
Book Title:
Advances in Alzheimer's Disease Volume 4: Handbook of Depression in Alzheimer's Disease
Authors:
Khundakar, A.A. ( 0000-0002-4835-5359 ) ; Thomas, A. J. (Alan)
Editors:
Smith, G. (Gwenn)
Affiliation:
Teesside University. Technology Futures Institute
Citation:
Khundakar, A.A., Thomas, A. J. (2015) 'Neuropathology of Depression in Alzheimer's Disease: Current Knowledge and the Potential for New Treatments' in Smith, G. Advances in Alzheimer's Disease Volume 4: Handbook of Depression in Alzheimer's Disease. Published online: IOS Press
Publisher:
IOS Press
Issue Date:
2015
URI:
http://hdl.handle.net/10149/621769
Additional Links:
http://ebooks.iospress.nl/volume/handbook-of-depression-in-alzheimers-disease
Abstract:
Depression is among the most common behavioural and psychological symptoms of dementia, and leads to more rapid decline and higher mortality. Treatment for depression in dementia has centred on conventional antidepressant drug treatment based around the monoamine hypothesis of depression. However, recent major studies have suggested that conventional antidepressant treatments that aim to correct underlying deficits in monoamine neurotransmitters are not effective for depression in dementia. Post-mortem studies have also suggested that depression in dementia does not arise from serotonergic or noradrenergic abnormalities, or indeed from the degenerative pathology associated with Alzheimer’s disease. In contrast, considerable recent evidence has suggested that alterations in glutamatergic transmission may contribute to the pathophysiology of depression. This supports the view that treatment-resistant depressed patients, such as many dementia patients, may benefit from agents affecting glutamate transmission. This review will thus draw together the wealth of pathological data examining the basis of depression in Alzheimer’s disease and relate this to current thinking on treatment, with the aim of generating discussion on potential novel therapeutic strategies.
Type:
Book Chapter
Language:
en
ISBN:
978-1-61499-542-5
Rights:
Publisher does not permit archiving full text on an institutional repository.

Full metadata record

DC FieldValue Language
dc.contributor.authorKhundakar, A.A.en
dc.contributor.authorThomas, A. J. (Alan)en
dc.contributor.editorSmith, G. (Gwenn)en
dc.date.accessioned2018-03-13T15:26:02Z-
dc.date.available2018-03-13T15:26:02Z-
dc.date.issued2015-
dc.identifier.isbn978-1-61499-542-5-
dc.identifier.urihttp://hdl.handle.net/10149/621769-
dc.description.abstractDepression is among the most common behavioural and psychological symptoms of dementia, and leads to more rapid decline and higher mortality. Treatment for depression in dementia has centred on conventional antidepressant drug treatment based around the monoamine hypothesis of depression. However, recent major studies have suggested that conventional antidepressant treatments that aim to correct underlying deficits in monoamine neurotransmitters are not effective for depression in dementia. Post-mortem studies have also suggested that depression in dementia does not arise from serotonergic or noradrenergic abnormalities, or indeed from the degenerative pathology associated with Alzheimer’s disease. In contrast, considerable recent evidence has suggested that alterations in glutamatergic transmission may contribute to the pathophysiology of depression. This supports the view that treatment-resistant depressed patients, such as many dementia patients, may benefit from agents affecting glutamate transmission. This review will thus draw together the wealth of pathological data examining the basis of depression in Alzheimer’s disease and relate this to current thinking on treatment, with the aim of generating discussion on potential novel therapeutic strategies.en
dc.language.isoenen
dc.publisherIOS Pressen
dc.relation.urlhttp://ebooks.iospress.nl/volume/handbook-of-depression-in-alzheimers-diseaseen
dc.rightsPublisher does not permit archiving full text on an institutional repository.en
dc.titleNeuropathology of Depression in Alzheimer's Disease: Current Knowledge and the Potential for New Treatmentsen
dc.typeBook Chapteren
dc.contributor.departmentTeesside University. Technology Futures Instituteen
dc.title.bookAdvances in Alzheimer's Disease Volume 4: Handbook of Depression in Alzheimer's Diseaseen
or.citation.harvardKhundakar, A.A., Thomas, A. J. (2015) 'Neuropathology of Depression in Alzheimer's Disease: Current Knowledge and the Potential for New Treatments' in Smith, G. Advances in Alzheimer's Disease Volume 4: Handbook of Depression in Alzheimer's Disease. Published online: IOS Pressen
dc.date.accepted2014-08-25-
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