Lifestyle factors and colorectal cancer risk (2): a systematic review and meta-analysis of associations with leisure-time physical activity

Hdl Handle:
http://hdl.handle.net/10149/91861
Title:
Lifestyle factors and colorectal cancer risk (2): a systematic review and meta-analysis of associations with leisure-time physical activity
Authors:
Harriss, D. J. (David); Atkinson, G. (Greg); Batterham, A. M. (Alan); George, K. P. (Keith); Cable, N. T. (Tim); Reilly, T. P. (Thomas); Haboubi, N. J. (Najib); Renehan, A. G. (Andrew)
Affiliation:
University of Teesside. Health and Social Care Institute.
Citation:
Harriss, D. J. et al. (2009) 'Lifestyle factors and colorectal cancer risk (2): a systematic review and meta-analysis of associations with leisure-time physical activity', Colorectal Disease, 11 (7), pp.689-701.
Publisher:
Wiley-Blackwell
Journal:
Colorectal Disease
Issue Date:
Jan-2009
URI:
http://hdl.handle.net/10149/91861
DOI:
10.1111/j.1463-1318.2009.01767.x
Abstract:
Objective: Increased physical activity may decrease the risk of colorectal cancer. As a prerequisite to the determination of lifestyle attributable risks, the authors performed a systematic review and meta-analysis of prospective observational studies to quantify gender-specific risk associated with increased leisure-time physical activity (LT-PA). Method: The authors searched MEDLINE and EMBASE (to December 2007), and other sources, selecting reports based on strict inclusion criteria. They used random-effects meta-analyses to estimate summary risk ratios (RR) and 95% confidence intervals (95% CI) for uppermost vs lowermost categories of physical activity. To investigate dose–response, the authors explored risks ratios as a function of cumulative percentiles of physical activity distribution. Results: Fifteen datasets from 14 articles, including 7873 incident cases, were identified. For colon cancer, there were inverse associations with LT-PA for men (RR: 0.80; 95% CI: 0.67–0.96) and women (0.86; 0.76–0.98). LT-PA did not influence risk of rectal cancer. The dose–response analysis was consistent with linear pattern reductions in risk of colon cancer in both genders. There was evidence of moderate between-study heterogeneity but summary estimates were broadly consistent across potential confounding factors. Conclusion: Increased LT-PA is associated with a modest reduction in colon but not rectal cancer risk; a risk reduction, which previously may have been overstated. LT-PA only interventions in public health cancer prevention strategies are unlikely to impact substantially on colorectal cancer incidences.
Type:
Article
Language:
en
Keywords:
colorectal cancer; physical activity; systematic review; meta-analysis; colon cancer; rectal cancer
ISSN:
1462-8910; 1463-1318
Rights:
Subject to restrictions, author can archive post-print (ie final draft post-refereeing). For full details see http://www.sherpa.ac.uk/romeo/ [Accessed 11/02/2010]
Citation Count:
3 [Scopus, 11/02/2010]

Full metadata record

DC FieldValue Language
dc.contributor.authorHarriss, D. J. (David)en
dc.contributor.authorAtkinson, G. (Greg)en
dc.contributor.authorBatterham, A. M. (Alan)en
dc.contributor.authorGeorge, K. P. (Keith)en
dc.contributor.authorCable, N. T. (Tim)en
dc.contributor.authorReilly, T. P. (Thomas)en
dc.contributor.authorHaboubi, N. J. (Najib)en
dc.contributor.authorRenehan, A. G. (Andrew)en
dc.date.accessioned2010-02-11T14:12:35Z-
dc.date.available2010-02-11T14:12:35Z-
dc.date.issued2009-01-
dc.identifier.citationColorectal Disease; 11 (7): 689-701en
dc.identifier.issn1462-8910-
dc.identifier.issn1463-1318-
dc.identifier.doi10.1111/j.1463-1318.2009.01767.x-
dc.identifier.urihttp://hdl.handle.net/10149/91861-
dc.description.abstractObjective: Increased physical activity may decrease the risk of colorectal cancer. As a prerequisite to the determination of lifestyle attributable risks, the authors performed a systematic review and meta-analysis of prospective observational studies to quantify gender-specific risk associated with increased leisure-time physical activity (LT-PA). Method: The authors searched MEDLINE and EMBASE (to December 2007), and other sources, selecting reports based on strict inclusion criteria. They used random-effects meta-analyses to estimate summary risk ratios (RR) and 95% confidence intervals (95% CI) for uppermost vs lowermost categories of physical activity. To investigate dose–response, the authors explored risks ratios as a function of cumulative percentiles of physical activity distribution. Results: Fifteen datasets from 14 articles, including 7873 incident cases, were identified. For colon cancer, there were inverse associations with LT-PA for men (RR: 0.80; 95% CI: 0.67–0.96) and women (0.86; 0.76–0.98). LT-PA did not influence risk of rectal cancer. The dose–response analysis was consistent with linear pattern reductions in risk of colon cancer in both genders. There was evidence of moderate between-study heterogeneity but summary estimates were broadly consistent across potential confounding factors. Conclusion: Increased LT-PA is associated with a modest reduction in colon but not rectal cancer risk; a risk reduction, which previously may have been overstated. LT-PA only interventions in public health cancer prevention strategies are unlikely to impact substantially on colorectal cancer incidences.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.rightsSubject to restrictions, author can archive post-print (ie final draft post-refereeing). For full details see http://www.sherpa.ac.uk/romeo/ [Accessed 11/02/2010]en
dc.subjectcolorectal canceren
dc.subjectphysical activityen
dc.subjectsystematic reviewen
dc.subjectmeta-analysisen
dc.subjectcolon canceren
dc.subjectrectal canceren
dc.titleLifestyle factors and colorectal cancer risk (2): a systematic review and meta-analysis of associations with leisure-time physical activityen
dc.typeArticleen
dc.contributor.departmentUniversity of Teesside. Health and Social Care Institute.en
dc.identifier.journalColorectal Diseaseen
ref.citationcount3 [Scopus, 11/02/2010]en
or.citation.harvardHarriss, D. J. et al. (2009) 'Lifestyle factors and colorectal cancer risk (2): a systematic review and meta-analysis of associations with leisure-time physical activity', Colorectal Disease, 11 (7), pp.689-701.-
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