Wholegrain cereals for coronary heart disease

Hdl Handle:
http://hdl.handle.net/10149/93496
Title:
Wholegrain cereals for coronary heart disease
Authors:
Kelly, S. A. M. (Sarah); Summerbell, C. D. (Carolyn); Brynes, A. (Audrey); Whittaker, V. J. (Victoria); Frost, G. (Gary)
Affiliation:
University of Teesside. School of Health and Social Care.
Citation:
Kelly, S. A. M. et al. (2007) 'Wholegrain cereals for coronary heart disease', The Cochrane Database of Systematic Reviews, 2 (Art. no. CD005051).
Publisher:
Wiley-Blackwell
Journal:
The Cochrane Database of Systematic Reviews
Issue Date:
2007
URI:
http://hdl.handle.net/10149/93496
DOI:
10.1002/14651858.CD005051.pub2
Abstract:
Background: There is increasing evidence from observational studies that wholegrains can have a beneficial effect on risk factors for coronary heart disease (CHD). Objectives: The primary objective is to review the current evidence from randomised controlled trials (RCTs) that assess the relationship between the consumption of wholegrain foods and the effects on CHD mortality, morbidity and on risk factors for CHD, in participants previously diagnosed with CHD or with existing risk factors for CHD. Search strategy: We searched CENTRAL (Issue 4, 2005), MEDLINE (1966 to 2005), EMBASE (1980 to 2005), CINAHL (1982 to 2005), ProQuest Digital Dissertations (2004 to 2005). No language restrictions were applied. Selection criteria: We selected randomised controlled trials that assessed the effects of wholegrain foods or diets containing wholegrains, over a minimum of 4 weeks, on CHD and risk factors. Participants included were adults with existing CHD or who had at least one risk factor for CHD, such as abnormal lipids, raised blood pressure or being overweight. Data collection and analysis: Two of our research team independently assessed trial quality and extracted data. Authors of the included studies were contacted for additional information where this was appropriate. Main results: Ten trials met the inclusion criteria. None of the studies found reported the effect of wholegrain diets on CHD mortality or CHD events or morbidity. All 10 included studies reported the effect of wholegrain foods or diets on risk factors for CHD. Studies ranged in duration from 4 to 8 weeks. In eight of the included studies, the wholegrain component was oats. Seven of the eight studies reported lower total and low density lipoproteins (LDL) cholesterol with oatmeal foods than control foods. When the studies were combined in a meta-analysis lower total cholesterol (-0.20 mmol/L, 95% confidence interval (CI) -0.31 to -0.10, P = 0.0001 ) and LDL cholesterol (0.18 mmol/L, 95% CI -0.28 to -0.09, P < 0.0001) were found with oatmeal foods. However, there is a lack of studies on other wholegrains or wholegrain diets. Authors' conclusions: Despite the consistency of effects seen in trials of wholegrain oats, the positive findings should be interpreted cautiously. Many of the trials identified were short term, of poor quality and had insufficient power. Most of the trials were funded by companies with commercial interests in wholegrains. There is a need for well-designed, adequately powered, longer term randomised controlled studies in this area. In particular there is a need for randomised controlled trials on wholegrain foods and diets other than oats.
Type:
Article
Language:
en
Keywords:
cereals; cholesterol; coronary heart disease; CHD; randomized controlled trial; wholegrain; mortality; morbidity
ISSN:
1469-493X
Rights:
In return for the grant of the licence, the author(s) shall have the following rights: The right to post the review as an electronic file on the author's own website and/or the author's institution's website, using the PDF version of the review available in the Cochrane Database of Systematic Reviews. [Advice from CEO of The Cochrane Collaboration]
Citation Count:
5 [Scopus, 03/03/2010]

Full metadata record

DC FieldValue Language
dc.contributor.authorKelly, S. A. M. (Sarah)en
dc.contributor.authorSummerbell, C. D. (Carolyn)en
dc.contributor.authorBrynes, A. (Audrey)en
dc.contributor.authorWhittaker, V. J. (Victoria)en
dc.contributor.authorFrost, G. (Gary)en
dc.date.accessioned2010-03-03T10:44:34Z-
dc.date.available2010-03-03T10:44:34Z-
dc.date.issued2007-
dc.identifier.citationThe Cochrane Database of Systematic Reviews; 2 (Art. no. CD005051)en
dc.identifier.issn1469-493X-
dc.identifier.doi10.1002/14651858.CD005051.pub2-
dc.identifier.urihttp://hdl.handle.net/10149/93496-
dc.description.abstractBackground: There is increasing evidence from observational studies that wholegrains can have a beneficial effect on risk factors for coronary heart disease (CHD). Objectives: The primary objective is to review the current evidence from randomised controlled trials (RCTs) that assess the relationship between the consumption of wholegrain foods and the effects on CHD mortality, morbidity and on risk factors for CHD, in participants previously diagnosed with CHD or with existing risk factors for CHD. Search strategy: We searched CENTRAL (Issue 4, 2005), MEDLINE (1966 to 2005), EMBASE (1980 to 2005), CINAHL (1982 to 2005), ProQuest Digital Dissertations (2004 to 2005). No language restrictions were applied. Selection criteria: We selected randomised controlled trials that assessed the effects of wholegrain foods or diets containing wholegrains, over a minimum of 4 weeks, on CHD and risk factors. Participants included were adults with existing CHD or who had at least one risk factor for CHD, such as abnormal lipids, raised blood pressure or being overweight. Data collection and analysis: Two of our research team independently assessed trial quality and extracted data. Authors of the included studies were contacted for additional information where this was appropriate. Main results: Ten trials met the inclusion criteria. None of the studies found reported the effect of wholegrain diets on CHD mortality or CHD events or morbidity. All 10 included studies reported the effect of wholegrain foods or diets on risk factors for CHD. Studies ranged in duration from 4 to 8 weeks. In eight of the included studies, the wholegrain component was oats. Seven of the eight studies reported lower total and low density lipoproteins (LDL) cholesterol with oatmeal foods than control foods. When the studies were combined in a meta-analysis lower total cholesterol (-0.20 mmol/L, 95% confidence interval (CI) -0.31 to -0.10, P = 0.0001 ) and LDL cholesterol (0.18 mmol/L, 95% CI -0.28 to -0.09, P < 0.0001) were found with oatmeal foods. However, there is a lack of studies on other wholegrains or wholegrain diets. Authors' conclusions: Despite the consistency of effects seen in trials of wholegrain oats, the positive findings should be interpreted cautiously. Many of the trials identified were short term, of poor quality and had insufficient power. Most of the trials were funded by companies with commercial interests in wholegrains. There is a need for well-designed, adequately powered, longer term randomised controlled studies in this area. In particular there is a need for randomised controlled trials on wholegrain foods and diets other than oats.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.rightsIn return for the grant of the licence, the author(s) shall have the following rights: The right to post the review as an electronic file on the author's own website and/or the author's institution's website, using the PDF version of the review available in the Cochrane Database of Systematic Reviews. [Advice from CEO of The Cochrane Collaboration]en
dc.subjectcerealsen
dc.subjectcholesterolen
dc.subjectcoronary heart diseaseen
dc.subjectCHDen
dc.subjectrandomized controlled trialen
dc.subjectwholegrainen
dc.subjectmortalityen
dc.subjectmorbidityen
dc.titleWholegrain cereals for coronary heart diseaseen
dc.typeArticleen
dc.contributor.departmentUniversity of Teesside. School of Health and Social Care.en
dc.identifier.journalThe Cochrane Database of Systematic Reviewsen
ref.citationcount5 [Scopus, 03/03/2010]en
or.citation.harvardKelly, S. A. M. et al. (2007) 'Wholegrain cereals for coronary heart disease', The Cochrane Database of Systematic Reviews, 2 (Art. no. CD005051).-
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