From animal cage to aircraft cabin: An overview of evidence translation in jet lag research

Hdl Handle:
http://hdl.handle.net/10149/337337
Title:
From animal cage to aircraft cabin: An overview of evidence translation in jet lag research
Authors:
Atkinson, G. (Greg); Batterham, A. M. (Alan); Dowdall, N. (Nigel); Thompson, A. (Andrew); van Drongelen, A. (Alwin)
Affiliation:
Teesside University. Health and Social Care Institute.
Citation:
Atkinson, G., Batterham, A. M., Dowdall, N., Thompson, A., van Drongelen, A. (2014) 'From animal cage to aircraft cabin: An overview of evidence translation in jet lag research' European Journal of Applied Physiology; 114 (12): pp2459-2468
Publisher:
Springer
Journal:
European Journal of Applied Physiology
Issue Date:
1-Dec-2014
URI:
http://hdl.handle.net/10149/337337
DOI:
10.1007/s00421-014-3026-3
Additional Links:
http://link.springer.com/article/10.1007%2Fs00421-014-3026-3
Abstract:
Recent laboratory experiments on rodents have increased our understanding of circadian rhythm mechanisms. Typically, circadian biologists attempt to translate their laboratory-based findings to treatment of jet lag symptoms in humans. We aimed to scrutinise the strength of the various links in the translational pathway from animal model to human traveller. First, we argue that the translation of findings from pre-clinical studies to effective jet lag treatments and knowledge regarding longer-term population health is not robust, e.g. the association between circadian disruption and cancer found in animal models does not translate well to cabin crew and pilots, who have a lower risk of most cancers. Jet lag symptoms are heterogeneous, making the true prevalence and the effects of any intervention difficult to quantify precisely. The mechanistic chain between in vitro and in vivo treatment effects has weak links, especially between circadian rhythm disruption in animals and the improvement of jet lag symptoms in humans. While the number of animal studies has increased exponentially between 1990 and 2014, only 1–2 randomised controlled trials on jet lag treatments are published every year. There is one relevant Cochrane review, in which only 2–4 studies on melatonin, without baseline measures, were meta-analysed. Study effect sizes reduced substantially between 1987, when the first paper on melatonin was published, and 2000. We suggest that knowledge derived from a greater number of human randomised controlled trials would provide a firmer platform for circadian biologists to cite jet lag treatment as an important application of their findings.
Type:
Article
Language:
en
Keywords:
Human Physiology; Occupational medicine; industrial medicine; sports medicine
ISSN:
1439-6319
EISSN:
1439-6327
Rights:
Following 12 month embargo author can archive post-print (ie final draft post-refereeing). For full details see http://www.sherpa.ac.uk/romeo [Accessed: 17/12/2014]

Full metadata record

DC FieldValue Language
dc.contributor.authorAtkinson, G. (Greg)en
dc.contributor.authorBatterham, A. M. (Alan)en
dc.contributor.authorDowdall, N. (Nigel)en
dc.contributor.authorThompson, A. (Andrew)en
dc.contributor.authorvan Drongelen, A. (Alwin)en
dc.date.accessioned2014-12-17T16:03:49Z-
dc.date.available2014-12-17T16:03:49Z-
dc.date.issued2014-12-01-
dc.identifier.citationEuropean Journal of Applied Physiology; 114 (12): pp2459-2468en
dc.identifier.issn1439-6319-
dc.identifier.doi10.1007/s00421-014-3026-3-
dc.identifier.urihttp://hdl.handle.net/10149/337337-
dc.description.abstractRecent laboratory experiments on rodents have increased our understanding of circadian rhythm mechanisms. Typically, circadian biologists attempt to translate their laboratory-based findings to treatment of jet lag symptoms in humans. We aimed to scrutinise the strength of the various links in the translational pathway from animal model to human traveller. First, we argue that the translation of findings from pre-clinical studies to effective jet lag treatments and knowledge regarding longer-term population health is not robust, e.g. the association between circadian disruption and cancer found in animal models does not translate well to cabin crew and pilots, who have a lower risk of most cancers. Jet lag symptoms are heterogeneous, making the true prevalence and the effects of any intervention difficult to quantify precisely. The mechanistic chain between in vitro and in vivo treatment effects has weak links, especially between circadian rhythm disruption in animals and the improvement of jet lag symptoms in humans. While the number of animal studies has increased exponentially between 1990 and 2014, only 1–2 randomised controlled trials on jet lag treatments are published every year. There is one relevant Cochrane review, in which only 2–4 studies on melatonin, without baseline measures, were meta-analysed. Study effect sizes reduced substantially between 1987, when the first paper on melatonin was published, and 2000. We suggest that knowledge derived from a greater number of human randomised controlled trials would provide a firmer platform for circadian biologists to cite jet lag treatment as an important application of their findings.en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.urlhttp://link.springer.com/article/10.1007%2Fs00421-014-3026-3en
dc.rightsFollowing 12 month embargo author can archive post-print (ie final draft post-refereeing). For full details see http://www.sherpa.ac.uk/romeo [Accessed: 17/12/2014]en
dc.subjectHuman Physiologyen
dc.subjectOccupational medicineen
dc.subjectindustrial medicineen
dc.subjectsports medicineen
dc.titleFrom animal cage to aircraft cabin: An overview of evidence translation in jet lag researchen
dc.typeArticleen
dc.identifier.eissn1439-6327-
dc.contributor.departmentTeesside University. Health and Social Care Institute.en
dc.identifier.journalEuropean Journal of Applied Physiologyen
or.citation.harvardAtkinson, G., Batterham, A. M., Dowdall, N., Thompson, A., van Drongelen, A. (2014) 'From animal cage to aircraft cabin: An overview of evidence translation in jet lag research' European Journal of Applied Physiology; 114 (12): pp2459-2468-
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