The effects of chronic trans-resveratrol supplementation on aspects of cognitive function, mood, sleep, health and cerebral blood flow in healthy, young humans

Hdl Handle:
http://hdl.handle.net/10149/581316
Title:
The effects of chronic trans-resveratrol supplementation on aspects of cognitive function, mood, sleep, health and cerebral blood flow in healthy, young humans
Authors:
Wightman, E. L. (Emma); Haskell-Ramsay, C. F. (Crystal); Reay, J. L. (Jonathon); Williamson, G. (Gary); Dew, T. (Tristan); Zhang, W. (Wei); Kennedy, D. O. (David)
Affiliation:
Teesside University. Social Futures Institute
Citation:
Wightman, E. L., Haskell-Ramsay, C. F., Reay, J. L., Williamson, G., Dew, T., Zhang, W., Kennedy, D. O. (2015) 'The effects of chronic trans-resveratrol supplementation on aspects of cognitive function, mood, sleep, health and cerebral blood flow in healthy, young humans' British Journal of Nutrition; 114 (09):1427
Publisher:
Cambridge University Press
Journal:
British Journal of Nutrition
Issue Date:
7-Sep-2015
URI:
http://hdl.handle.net/10149/581316
DOI:
10.1017/S0007114515003037
Additional Links:
http://www.journals.cambridge.org/abstract_S0007114515003037
Abstract:
Single doses of resveratrol have previously been shown to increase cerebral blood flow (CBF) with no clear effect on cognitive function or mood in healthy adults. Chronic resveratrol consumption may increase the poor bioavailability of resveratrol or otherwise potentiate its psychological effects. In this randomised, double-blind, placebo-controlled, parallel-groups study, a total of sixty adults aged between 18 and 30 years received either placebo or resveratrol for 28 d. On the 1st and 28th day of treatment, the performance of cognitively demanding tasks (serial subtractions, rapid visual information processing and 3-Back) ( n 41 complete data sets) was assessed, alongside blood pressure ( n 26) and acute (near-IR spectroscopy (NIRS)) and chronic (transcranial Doppler) measures of CBF ( n 46). Subjective mood, sleep quality and health questionnaires were completed at weekly intervals ( n 53/54). The results showed that the cognitive effects of resveratrol on day 1 were restricted to more accurate but slower serial subtraction task performance. The only cognitive finding on day 28 was a beneficial effect of resveratrol on the accuracy of the 3-Back task before treatment consumption. Subjective ratings of ‘fatigue’ were significantly lower across the entire 28 d in the resveratrol condition. Resveratrol also resulted in modulation of CBF parameters on day 1, as assessed by NIRS, and significantly increased diastolic blood pressure on day 28. Levels of resveratrol metabolites were significantly higher both before and after the day’s treatment on day 28, in comparison with day 1. These results confirm the acute CBF effects of resveratrol and the lack of interpretable cognitive effects.
Type:
Article
Language:
en
ISSN:
0007-1145; 1475-2662
Rights:
Following 6 month embargo author can archive post-print (ie final draft post-refereeing). For full details see http://www.sherpa.ac.uk/romeo [Accessed: 27/10/2015]

Full metadata record

DC FieldValue Language
dc.contributor.authorWightman, E. L. (Emma)en
dc.contributor.authorHaskell-Ramsay, C. F. (Crystal)en
dc.contributor.authorReay, J. L. (Jonathon)en
dc.contributor.authorWilliamson, G. (Gary)en
dc.contributor.authorDew, T. (Tristan)en
dc.contributor.authorZhang, W. (Wei)en
dc.contributor.authorKennedy, D. O. (David)en
dc.date.accessioned2015-10-27T16:37:38Zen
dc.date.available2015-10-27T16:37:38Zen
dc.date.issued2015-09-07en
dc.identifier.citationBritish Journal of Nutrition; 114 (09):1427en
dc.identifier.issn0007-1145en
dc.identifier.issn1475-2662en
dc.identifier.doi10.1017/S0007114515003037en
dc.identifier.urihttp://hdl.handle.net/10149/581316en
dc.description.abstractSingle doses of resveratrol have previously been shown to increase cerebral blood flow (CBF) with no clear effect on cognitive function or mood in healthy adults. Chronic resveratrol consumption may increase the poor bioavailability of resveratrol or otherwise potentiate its psychological effects. In this randomised, double-blind, placebo-controlled, parallel-groups study, a total of sixty adults aged between 18 and 30 years received either placebo or resveratrol for 28 d. On the 1st and 28th day of treatment, the performance of cognitively demanding tasks (serial subtractions, rapid visual information processing and 3-Back) ( n 41 complete data sets) was assessed, alongside blood pressure ( n 26) and acute (near-IR spectroscopy (NIRS)) and chronic (transcranial Doppler) measures of CBF ( n 46). Subjective mood, sleep quality and health questionnaires were completed at weekly intervals ( n 53/54). The results showed that the cognitive effects of resveratrol on day 1 were restricted to more accurate but slower serial subtraction task performance. The only cognitive finding on day 28 was a beneficial effect of resveratrol on the accuracy of the 3-Back task before treatment consumption. Subjective ratings of ‘fatigue’ were significantly lower across the entire 28 d in the resveratrol condition. Resveratrol also resulted in modulation of CBF parameters on day 1, as assessed by NIRS, and significantly increased diastolic blood pressure on day 28. Levels of resveratrol metabolites were significantly higher both before and after the day’s treatment on day 28, in comparison with day 1. These results confirm the acute CBF effects of resveratrol and the lack of interpretable cognitive effects.en
dc.language.isoenen
dc.publisherCambridge University Pressen
dc.relation.urlhttp://www.journals.cambridge.org/abstract_S0007114515003037en
dc.rightsFollowing 6 month embargo author can archive post-print (ie final draft post-refereeing). For full details see http://www.sherpa.ac.uk/romeo [Accessed: 27/10/2015]en
dc.titleThe effects of chronic trans-resveratrol supplementation on aspects of cognitive function, mood, sleep, health and cerebral blood flow in healthy, young humansen
dc.typeArticleen
dc.contributor.departmentTeesside University. Social Futures Instituteen
dc.identifier.journalBritish Journal of Nutritionen
or.citation.harvardWightman, E. L., Haskell-Ramsay, C. F., Reay, J. L., Williamson, G., Dew, T., Zhang, W., Kennedy, D. O. (2015) 'The effects of chronic trans-resveratrol supplementation on aspects of cognitive function, mood, sleep, health and cerebral blood flow in healthy, young humans' British Journal of Nutrition; 114 (09):1427en
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