Differential Apicobasal VEGF Signaling at Vascular Blood-Neural Barriers

Hdl Handle:
http://hdl.handle.net/10149/581599
Title:
Differential Apicobasal VEGF Signaling at Vascular Blood-Neural Barriers
Authors:
Hudson, N. (Natalie); Powner, M. B. (Michael); Sarker, M. H. (Mosharraf); Burgoyne, T. (Thomas); Campbell, M. (Matthew); Ockrim, Z. K. (Zoe); Martinelli, R. (Roberta); Futter, Clare E.; Grant, M. B. (Maria); Fraser, P. A. (Paul); Shima, D. T. (David); Greenwood, J. (John); Turowski, P. (Patric)
Affiliation:
Teesside University, Technology Futures Institute
Citation:
Hudson, N.; Powner, M. B.; Sarker, M. H.; Burgoyne, T.; Campbell, M.; Ockrim, Z. K.; Martinelli, R.; Futter, C. E.; Grant, M. B.; Fraser, P. A.; Shima, D. T.; Greenwood, J.; Turowski, P. (2014) 'Differential Apicobasal VEGF Signaling at Vascular Blood-Neural Barriers' Developmental Cell; 30(5) : 541-552
Journal:
Developmental Cell
Issue Date:
Sep-2014
URI:
http://hdl.handle.net/10149/581599
DOI:
10.1016/j.devcel.2014.06.027
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S153458071400416X
Abstract:
The vascular endothelium operates in a highly polarized environment, but to date there has been little exploration of apicobasal polarization of its signaling. We show that VEGF-A, histamine, IGFBP3, and LPA trigger unequal endothelial responses when acting from the circulation or the parenchymal side at blood-neural barriers. For VEGF-A, highly polarized receptor distribution contributed to distinct signaling patterns: VEGFR2, which was found to be predominantly abluminal, mediated increased permeability via p38; in contrast, luminal VEGFR1 led to Akt activation and facilitated cytoprotection. Importantly, such differential apicobasal signaling and VEGFR distribution were found in the microvasculature of brain and retina but not lung, indicating that endothelial cells at blood-neural barriers possess specialized signaling compartments that assign different functions depending on whether an agonist is tissue or blood borne.
Type:
Article
Language:
en
ISSN:
15345807
Rights:
Published under a Creative Commons licence. For details see http://creativecommons.org/licenses/by/3.0/

Full metadata record

DC FieldValue Language
dc.contributor.authorHudson, N. (Natalie)en
dc.contributor.authorPowner, M. B. (Michael)en
dc.contributor.authorSarker, M. H. (Mosharraf)en
dc.contributor.authorBurgoyne, T. (Thomas)en
dc.contributor.authorCampbell, M. (Matthew)en
dc.contributor.authorOckrim, Z. K. (Zoe)en
dc.contributor.authorMartinelli, R. (Roberta)en
dc.contributor.authorFutter, Clare E.en
dc.contributor.authorGrant, M. B. (Maria)en
dc.contributor.authorFraser, P. A. (Paul)en
dc.contributor.authorShima, D. T. (David)en
dc.contributor.authorGreenwood, J. (John)en
dc.contributor.authorTurowski, P. (Patric)en
dc.date.accessioned2015-11-03T15:30:02Zen
dc.date.available2015-11-03T15:30:02Zen
dc.date.issued2014-09en
dc.identifier.citationDevelopmental Cell; 30(5) : 541-552en
dc.identifier.issn15345807en
dc.identifier.doi10.1016/j.devcel.2014.06.027en
dc.identifier.urihttp://hdl.handle.net/10149/581599en
dc.description.abstractThe vascular endothelium operates in a highly polarized environment, but to date there has been little exploration of apicobasal polarization of its signaling. We show that VEGF-A, histamine, IGFBP3, and LPA trigger unequal endothelial responses when acting from the circulation or the parenchymal side at blood-neural barriers. For VEGF-A, highly polarized receptor distribution contributed to distinct signaling patterns: VEGFR2, which was found to be predominantly abluminal, mediated increased permeability via p38; in contrast, luminal VEGFR1 led to Akt activation and facilitated cytoprotection. Importantly, such differential apicobasal signaling and VEGFR distribution were found in the microvasculature of brain and retina but not lung, indicating that endothelial cells at blood-neural barriers possess specialized signaling compartments that assign different functions depending on whether an agonist is tissue or blood borne.en
dc.language.isoenen
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S153458071400416Xen
dc.rightsPublished under a Creative Commons licence. For details see http://creativecommons.org/licenses/by/3.0/en
dc.titleDifferential Apicobasal VEGF Signaling at Vascular Blood-Neural Barriersen
dc.typeArticleen
dc.contributor.departmentTeesside University, Technology Futures Instituteen
dc.identifier.journalDevelopmental Cellen
or.citation.harvardHudson, N.; Powner, M. B.; Sarker, M. H.; Burgoyne, T.; Campbell, M.; Ockrim, Z. K.; Martinelli, R.; Futter, C. E.; Grant, M. B.; Fraser, P. A.; Shima, D. T.; Greenwood, J.; Turowski, P. (2014) 'Differential Apicobasal VEGF Signaling at Vascular Blood-Neural Barriers' Developmental Cell; 30(5) : 541-552en
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