Brachial artery diameter, but not flow-mediated dilation, is associated with sleep apnoea in the Multi-Ethnic Study of Atherosclerosis

Hdl Handle:
http://hdl.handle.net/10149/582099
Title:
Brachial artery diameter, but not flow-mediated dilation, is associated with sleep apnoea in the Multi-Ethnic Study of Atherosclerosis
Authors:
Atkinson, G. (Greg); Danjoux, G. R. (Gerard); Ells, L. J. (Louisa); Suri, S. (Sophie); Batterham, A. M. (Alan)
Affiliation:
Teesside University, Health and Social Care Institute
Citation:
Atkinson, G., Danjoux, G., Ells, L. Suri, S., Batterham, A.M. (2016) "Brachial artery diameter, but not flow-mediated dilation, is associated with sleep apnoea in the Multi-Ethnic Study of Atherosclerosis" Journal of Hypertension; 34(3):410-3
Publisher:
Lippincott, Williams & Wilkins
Journal:
Journal of Hypertension
Issue Date:
1-Mar-2016
URI:
http://hdl.handle.net/10149/582099
DOI:
10.1097/HJH.0000000000000808
Abstract:
The percentage flow-mediated dilation of the brachial artery (FMD%) is purported to be an early indicator of atherosclerosis and has been reported to be reduced in people with obstructive sleep apnoea. Nevertheless, FMD% scales poorly for, and is concomitantly dependent on, initial artery diameter, which may, itself, be higher in obstructive sleep apnoea patients. Therefore, for the first time, we aimed to quantify the differences in initial diameter and properly-scaled flow-mediated dilation between people with, and without, sleep apnoea. The prevalence of physician-diagnosed sleep apnoea, as well as initial and peak diameters of the brachial artery were recorded for 3354 participants in the Multi-Ethnic Study of Atherosclerosis (MESA). Arterial data were analysed using FMD% and an allometric approach, which scales the flow-mediated response properly for initial diameter. In the sex, race and age-adjusted model, initial diameter was 0.19 mm larger in sleep apnoea patients (95%CI: 0.07 to 0.32 mm, P=0.003) and correlated negatively with FMD% (r= -0.43, 95%CI: -0.57 to -0.26, P<0.0005). Using this same adjusted model, FMD% was 3.8±2.7% for sleep apnoea patients (n=104) vs 4.4±2.7% for undiagnosed people (95%CI for difference: -1.12 to -0.07%, P=0.028). Allometric scaling halved this FMD%-indicated sample difference in flow-mediated dilation (95%CI: -0.7% to 0.1%, P=0.19). In conclusion, the initial diameter of the brachial artery is larger in MESA participants diagnosed with sleep apnoea compared with undiagnosed people. However, the difference in flow-mediated dilation between these two cohorts is trivial when the flow-mediated response is scaled properly for resting diameter.
Type:
Article
Language:
en
Keywords:
Sleep apnoea; Endothelial function; Biostatistics; Biostatistics
ISSN:
0263-6352
EISSN:
1473-5598
Rights:
Following 12 month embargo author can archive post-print (ie final draft post-refereeing). For full details see http://www.sherpa.ac.uk/romeo/search.php [accessed 12.11.15]

Full metadata record

DC FieldValue Language
dc.contributor.authorAtkinson, G. (Greg)en
dc.contributor.authorDanjoux, G. R. (Gerard)en
dc.contributor.authorElls, L. J. (Louisa)en
dc.contributor.authorSuri, S. (Sophie)en
dc.contributor.authorBatterham, A. M. (Alan)en
dc.date.accessioned2015-11-12T11:57:20Zen
dc.date.available2015-11-12T11:57:20Zen
dc.date.issued2016-03-01en
dc.identifier.citationJournal of Hypertension; 34 (3): 410-3en
dc.identifier.issn0263-6352en
dc.identifier.doi10.1097/HJH.0000000000000808-
dc.identifier.urihttp://hdl.handle.net/10149/582099en
dc.description.abstractThe percentage flow-mediated dilation of the brachial artery (FMD%) is purported to be an early indicator of atherosclerosis and has been reported to be reduced in people with obstructive sleep apnoea. Nevertheless, FMD% scales poorly for, and is concomitantly dependent on, initial artery diameter, which may, itself, be higher in obstructive sleep apnoea patients. Therefore, for the first time, we aimed to quantify the differences in initial diameter and properly-scaled flow-mediated dilation between people with, and without, sleep apnoea. The prevalence of physician-diagnosed sleep apnoea, as well as initial and peak diameters of the brachial artery were recorded for 3354 participants in the Multi-Ethnic Study of Atherosclerosis (MESA). Arterial data were analysed using FMD% and an allometric approach, which scales the flow-mediated response properly for initial diameter. In the sex, race and age-adjusted model, initial diameter was 0.19 mm larger in sleep apnoea patients (95%CI: 0.07 to 0.32 mm, P=0.003) and correlated negatively with FMD% (r= -0.43, 95%CI: -0.57 to -0.26, P<0.0005). Using this same adjusted model, FMD% was 3.8±2.7% for sleep apnoea patients (n=104) vs 4.4±2.7% for undiagnosed people (95%CI for difference: -1.12 to -0.07%, P=0.028). Allometric scaling halved this FMD%-indicated sample difference in flow-mediated dilation (95%CI: -0.7% to 0.1%, P=0.19). In conclusion, the initial diameter of the brachial artery is larger in MESA participants diagnosed with sleep apnoea compared with undiagnosed people. However, the difference in flow-mediated dilation between these two cohorts is trivial when the flow-mediated response is scaled properly for resting diameter.en
dc.language.isoenen
dc.publisherLippincott, Williams & Wilkinsen
dc.rightsFollowing 12 month embargo author can archive post-print (ie final draft post-refereeing). For full details see http://www.sherpa.ac.uk/romeo/search.php [accessed 12.11.15]en
dc.subjectSleep apnoeaen
dc.subjectEndothelial functionen
dc.subjectBiostatisticsen
dc.subjectBiostatisticsen
dc.titleBrachial artery diameter, but not flow-mediated dilation, is associated with sleep apnoea in the Multi-Ethnic Study of Atherosclerosisen
dc.typeArticleen
dc.identifier.eissn1473-5598en
dc.contributor.departmentTeesside University, Health and Social Care Instituteen
dc.identifier.journalJournal of Hypertensionen
or.citation.harvardAtkinson, G., Danjoux, G., Ells, L. Suri, S., Batterham, A.M. (2016) "Brachial artery diameter, but not flow-mediated dilation, is associated with sleep apnoea in the Multi-Ethnic Study of Atherosclerosis" Journal of Hypertension; 34(3):410-3en
dc.date.accepted2015-10-23en
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