Effect of exercise on fluoride metabolism in adult humans: a pilot study

Hdl Handle:
http://hdl.handle.net/10149/582356
Title:
Effect of exercise on fluoride metabolism in adult humans: a pilot study
Authors:
Zohoori, F. V. (Fatemeh Vida); Innerd, A. (Alison); Azevedo, L. B. (Liane); Whitford, G. M. (Gary); Maguire, A. (Anne)
Affiliation:
Teesside University. Health and Social Care Institute
Citation:
Zohoori, F.V., Innerd, A., Azevedo, L.B., Whitford, G.M., Maguire, A., (2015) "Effect of exercise on fluoride metabolism in adult humans: a pilot study", Scientific Reports; published online 19 Nov 2015.
Publisher:
Nature Publishing Group
Journal:
Scientific Reports
Issue Date:
19-Nov-2015
URI:
http://hdl.handle.net/10149/582356
DOI:
doi:10.1038/srep16905
Abstract:
An understanding of all aspects of fluoride metabolism is critical to identify its biological effects and avoid fluoride toxicity in humans. Fluoride metabolism and subsequently its body retention may be affected by physiological responses to acute exercise. This pilot study investigated the effect of exercise on plasma fluoride concentration, urinary fluoride excretion and fluoride renal clearance following no exercise and three exercise intensity conditions in nine healthy adults after taking a 1-mg Fluoride tablet. After no, light, moderate and vigorous exercise, respectively, the mean (SD) baselineadjusted i) plasma fluoride concentration was 9.6(6.3), 11.4(6.3), 15.6(7.7) and 14.9(10.0) ng/ml; ii) rate of urinary fluoride excretion over 0-8h was 46(15), 44(22), 34(17) and 36(17) μg/h; and iii) rate of fluoride renal clearance was 26.5(9.0), 27.2(30.4), 13.1(20.4) and 18.3(34.9) ml/min. The observed trend of a rise in plasma fluoride concentration and decline in rate of fluoride renal clearance with increasing exercise intensity needs to be investigated in a larger trial. This study, which provides the first data on the effect of exercise with different intensities on fluoride metabolism in humans, informs sample size planning for any subsequent definitive trial, by providing a robust estimate of the variability of the effect.
Type:
Article
Language:
en
Keywords:
fluoride; renal excretion; exercise intensity
ISSN:
2045-2322
EISSN:
2045-2322
Rights:
Author can archive publisher's version/PDF. For full details see http://www.sherpa.ac.uk/romeo/search.php [accessed 18.11.15] Released with a Creative Commons Attribution License 4.0

Full metadata record

DC FieldValue Language
dc.contributor.authorZohoori, F. V. (Fatemeh Vida)en
dc.contributor.authorInnerd, A. (Alison)en
dc.contributor.authorAzevedo, L. B. (Liane)en
dc.contributor.authorWhitford, G. M. (Gary)en
dc.contributor.authorMaguire, A. (Anne)en
dc.date.accessioned2015-11-18T15:44:13Zen
dc.date.available2015-11-18T15:44:13Zen
dc.date.issued2015-11-19en
dc.identifier.citationScientific Reports; published online 19 Nov 2015.en
dc.identifier.issn2045-2322en
dc.identifier.doidoi:10.1038/srep16905en
dc.identifier.urihttp://hdl.handle.net/10149/582356en
dc.description.abstractAn understanding of all aspects of fluoride metabolism is critical to identify its biological effects and avoid fluoride toxicity in humans. Fluoride metabolism and subsequently its body retention may be affected by physiological responses to acute exercise. This pilot study investigated the effect of exercise on plasma fluoride concentration, urinary fluoride excretion and fluoride renal clearance following no exercise and three exercise intensity conditions in nine healthy adults after taking a 1-mg Fluoride tablet. After no, light, moderate and vigorous exercise, respectively, the mean (SD) baselineadjusted i) plasma fluoride concentration was 9.6(6.3), 11.4(6.3), 15.6(7.7) and 14.9(10.0) ng/ml; ii) rate of urinary fluoride excretion over 0-8h was 46(15), 44(22), 34(17) and 36(17) μg/h; and iii) rate of fluoride renal clearance was 26.5(9.0), 27.2(30.4), 13.1(20.4) and 18.3(34.9) ml/min. The observed trend of a rise in plasma fluoride concentration and decline in rate of fluoride renal clearance with increasing exercise intensity needs to be investigated in a larger trial. This study, which provides the first data on the effect of exercise with different intensities on fluoride metabolism in humans, informs sample size planning for any subsequent definitive trial, by providing a robust estimate of the variability of the effect.en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.rightsAuthor can archive publisher's version/PDF. For full details see http://www.sherpa.ac.uk/romeo/search.php [accessed 18.11.15] Released with a Creative Commons Attribution License 4.0en
dc.subjectfluorideen
dc.subjectrenal excretionen
dc.subjectexercise intensityen
dc.titleEffect of exercise on fluoride metabolism in adult humans: a pilot studyen
dc.typeArticleen
dc.identifier.eissn2045-2322en
dc.contributor.departmentTeesside University. Health and Social Care Instituteen
dc.identifier.journalScientific Reportsen
or.citation.harvardZohoori, F.V., Innerd, A., Azevedo, L.B., Whitford, G.M., Maguire, A., (2015) "Effect of exercise on fluoride metabolism in adult humans: a pilot study", Scientific Reports; published online 19 Nov 2015.en
dc.date.accepted2015-10-21en
All Items in TeesRep are protected by copyright, with all rights reserved, unless otherwise indicated.