Impedimetric microanalysis system for deep vein thrombosis point-of-care testing

Hdl Handle:
http://hdl.handle.net/10149/93816
Title:
Impedimetric microanalysis system for deep vein thrombosis point-of-care testing
Authors:
Jaffrezic-Renault, N. (Nicole); Korri-Youssoufi, H. (Hafsa); Kyselovic, J. (Jan); Auger, V. (Vincent); Abdelhamid, E. (Errachid); Mills, C. A. (Christopher); Strohhöfer, C. (Christof); Ali, Z. (Zulfiqur)
Affiliation:
University of Teesside
Citation:
Jaffrezic-Renault, N. et al. (2008) 'Impedimetric microanalysis system for deep vein thrombosis point-of-care testing', 30th Annual International IEEE EMBS Conference, Vancouver, British Columbia, Canada, August 20-24. IEEE.
Publisher:
IEEE
Conference:
30th Annual International IEEE EMBS Conference, Vancouver, British Columbia, Canada, August 20-24, 2008.
Issue Date:
Aug-2008
URI:
http://hdl.handle.net/10149/93816
Additional Links:
https://embs.papercept.net/conferences/scripts/abstract.pl?ConfID=8&Number=1776
Abstract:
Deep Vein Thrombosis (DVT) and the associated condition of Pulmonary Embolism (PE) are the most common cause of unexpected death in developed nations. DVT is an internal clot formed in one of the body's deep veins, typically in the leg. If a part of the clot breaks free and moves into the lung, it can lead to pulmonary embolism (PE) which is often fatal. D-dimer is a recognised marker for the diagnosis of thrombus and is routinely used by skilled technical staff as part of an ELISA technique in hospital laboratories. Current D-dimer point-of-care tests are not sufficiently quantitative to allow them to be used to exclude DVT/PE. As a consequence, clinicians need to rely on the use of expensive Doppler ultrasound imaging (DUS), creating additional pressure on national health services. The DUS examination can take several days, during which time heparin is required to be administered to the patient. There is increasing in the development of low cost Lab-on-a-chip systems that will allow chemical and biological processing by non-specialist staff. A low cost, easy to use, portable and quantitative device for DVT/PE would be highly desirable since it would provide reliable diagnosis and aid faster treatment and recovery as well as lower healthcare provider costs. The authors report on the development of a portable system for the quantification of D-dimer in whole blood through the use of a label-free impedimetric approach for monitoring ligand-receptor (antigen-antibody) immunoassay. The system, comprises a disposable cartridge, carrying receptor ontop electrochemical transducer and allowing sample transport, and a reusable portable hand-held reader. The electrochemical transducers being developed include three-point and inter-digitated electrodes (IDEs).
Type:
Meetings and Proceedings
Language:
en
Keywords:
microfluidic for diagnostics; microfabrication technologies; microfluidic techniques; methods and systems
Rights:
Author can archive publisher's version/PDF. For full details see http://www.sherpa.ac.uk/romeo/ [Accessed 08/03/2010]
Citation Count:
0 [Web of Science and Scopus, 08/03/2010]

Full metadata record

DC FieldValue Language
dc.contributor.authorJaffrezic-Renault, N. (Nicole)en
dc.contributor.authorKorri-Youssoufi, H. (Hafsa)en
dc.contributor.authorKyselovic, J. (Jan)en
dc.contributor.authorAuger, V. (Vincent)en
dc.contributor.authorAbdelhamid, E. (Errachid)en
dc.contributor.authorMills, C. A. (Christopher)en
dc.contributor.authorStrohhöfer, C. (Christof)en
dc.contributor.authorAli, Z. (Zulfiqur)en
dc.date.accessioned2010-03-08T12:04:28Z-
dc.date.available2010-03-08T12:04:28Z-
dc.date.issued2008-08-
dc.identifier.urihttp://hdl.handle.net/10149/93816-
dc.description.abstractDeep Vein Thrombosis (DVT) and the associated condition of Pulmonary Embolism (PE) are the most common cause of unexpected death in developed nations. DVT is an internal clot formed in one of the body's deep veins, typically in the leg. If a part of the clot breaks free and moves into the lung, it can lead to pulmonary embolism (PE) which is often fatal. D-dimer is a recognised marker for the diagnosis of thrombus and is routinely used by skilled technical staff as part of an ELISA technique in hospital laboratories. Current D-dimer point-of-care tests are not sufficiently quantitative to allow them to be used to exclude DVT/PE. As a consequence, clinicians need to rely on the use of expensive Doppler ultrasound imaging (DUS), creating additional pressure on national health services. The DUS examination can take several days, during which time heparin is required to be administered to the patient. There is increasing in the development of low cost Lab-on-a-chip systems that will allow chemical and biological processing by non-specialist staff. A low cost, easy to use, portable and quantitative device for DVT/PE would be highly desirable since it would provide reliable diagnosis and aid faster treatment and recovery as well as lower healthcare provider costs. The authors report on the development of a portable system for the quantification of D-dimer in whole blood through the use of a label-free impedimetric approach for monitoring ligand-receptor (antigen-antibody) immunoassay. The system, comprises a disposable cartridge, carrying receptor ontop electrochemical transducer and allowing sample transport, and a reusable portable hand-held reader. The electrochemical transducers being developed include three-point and inter-digitated electrodes (IDEs).en
dc.language.isoenen
dc.publisherIEEEen
dc.relation.urlhttps://embs.papercept.net/conferences/scripts/abstract.pl?ConfID=8&Number=1776en
dc.rightsAuthor can archive publisher's version/PDF. For full details see http://www.sherpa.ac.uk/romeo/ [Accessed 08/03/2010]en
dc.subjectmicrofluidic for diagnosticsen
dc.subjectmicrofabrication technologiesen
dc.subjectmicrofluidic techniquesen
dc.subjectmethods and systemsen
dc.titleImpedimetric microanalysis system for deep vein thrombosis point-of-care testingen
dc.typeMeetings and Proceedingsen
dc.contributor.departmentUniversity of Teessideen
dc.identifier.conference30th Annual International IEEE EMBS Conference, Vancouver, British Columbia, Canada, August 20-24, 2008.en
ref.citationcount0 [Web of Science and Scopus, 08/03/2010]en
or.citation.harvardJaffrezic-Renault, N. et al. (2008) 'Impedimetric microanalysis system for deep vein thrombosis point-of-care testing', 30th Annual International IEEE EMBS Conference, Vancouver, British Columbia, Canada, August 20-24. IEEE.-
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