Kinetic study of the indomethacin synthesis and thermal decomposition reactions

Hdl Handle:
http://hdl.handle.net/10149/98966
Title:
Kinetic study of the indomethacin synthesis and thermal decomposition reactions
Authors:
Rusu, M. (Mariana); Olea, M. (Maria); Rusu, D. (Dan)
Affiliation:
Babes-Bolyai University. Faculty of Chemistry and Chemical Engineering.
Citation:
Rusu, M., Olea, M. and Rusu, D. (2000) 'Kinetic study of the indomethacin synthesis and thermal decomposition reactions', Journal of Pharmaceutical and Biomedical Analysis, 24 (1), pp.19-24.
Publisher:
Elsevier
Journal:
Journal of Pharmaceutical and Biomedical Analysis
Issue Date:
1-Dec-2000
URI:
http://hdl.handle.net/10149/98966
DOI:
10.1016/S0731-7085(00)00407-6
Abstract:
The kinetics of indomethacin synthesis (achieved through a new method) was studied at 80°C. The reaction proceeds in four steps. In the first step, by the condensation of levulinic acid with p-chlorobenzoyl-p-methoxy- phenylhydrazine in homogeneous acidic catalysis an intermediate is formed. In the second step, by the isomerisation of this intermediate a hydrazo compound is formed. In the third step, the isomerisation is followed by the o- benzydinic transposition of the reaction product mentioned above. In the fourth step, indomethacin is formed through a cyclization reaction. The rate constant of the indomethacin synthesis reaction was determined assuming that the cyclization reaction constitutes the rate-determining step. Spectrophotometric methods were used both in order to investigate the kinetics of the synthesis reaction and to verify the proposed mechanism. Then, a thermogravimetric study was performed on the purpose of finding out the temperature range in which indomethacin is stable. From the thermogravimetric curve kinetic parameters have been derived, using different calculation techniques.
Type:
Article
Language:
en
Keywords:
indomethacin; kinetics; Spectrophotometric analysis; thermal analysis
ISSN:
0731-7085
Rights:
Author can archive post-print (ie final draft post-refereeing). For full details see http://www.sherpa.ac.uk/romeo/ [Accessed 17/05/2010]
Citation Count:
0 [Scopus, 17/05/2010]

Full metadata record

DC FieldValue Language
dc.contributor.authorRusu, M. (Mariana)en
dc.contributor.authorOlea, M. (Maria)en
dc.contributor.authorRusu, D. (Dan)en
dc.date.accessioned2010-05-17T10:35:26Z-
dc.date.available2010-05-17T10:35:26Z-
dc.date.issued2000-12-01-
dc.identifier.citationJournal of Pharmaceutical and Biomedical Analysis; 24(1):19-24en
dc.identifier.issn0731-7085-
dc.identifier.doi10.1016/S0731-7085(00)00407-6-
dc.identifier.urihttp://hdl.handle.net/10149/98966-
dc.description.abstractThe kinetics of indomethacin synthesis (achieved through a new method) was studied at 80°C. The reaction proceeds in four steps. In the first step, by the condensation of levulinic acid with p-chlorobenzoyl-p-methoxy- phenylhydrazine in homogeneous acidic catalysis an intermediate is formed. In the second step, by the isomerisation of this intermediate a hydrazo compound is formed. In the third step, the isomerisation is followed by the o- benzydinic transposition of the reaction product mentioned above. In the fourth step, indomethacin is formed through a cyclization reaction. The rate constant of the indomethacin synthesis reaction was determined assuming that the cyclization reaction constitutes the rate-determining step. Spectrophotometric methods were used both in order to investigate the kinetics of the synthesis reaction and to verify the proposed mechanism. Then, a thermogravimetric study was performed on the purpose of finding out the temperature range in which indomethacin is stable. From the thermogravimetric curve kinetic parameters have been derived, using different calculation techniques.en
dc.language.isoenen
dc.publisherElsevieren
dc.rightsAuthor can archive post-print (ie final draft post-refereeing). For full details see http://www.sherpa.ac.uk/romeo/ [Accessed 17/05/2010]en
dc.subjectindomethacinen
dc.subjectkineticsen
dc.subjectSpectrophotometric analysisen
dc.subjectthermal analysisen
dc.titleKinetic study of the indomethacin synthesis and thermal decomposition reactionsen
dc.typeArticleen
dc.contributor.departmentBabes-Bolyai University. Faculty of Chemistry and Chemical Engineering.en
dc.identifier.journalJournal of Pharmaceutical and Biomedical Analysisen
ref.citationcount0 [Scopus, 17/05/2010]en
or.citation.harvardRusu, M., Olea, M. and Rusu, D. (2000) 'Kinetic study of the indomethacin synthesis and thermal decomposition reactions', Journal of Pharmaceutical and Biomedical Analysis, 24 (1), pp.19-24.-
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